成人VR视频

New vaccine set for human trials in Nipah outbreak hotspot

成人VR视频
Indian pteropus fruit bat feeding on honey from a banana tree

10 July 2025; OSLO - A promising vaccine candidate against one of the world鈥檚 most deadly viruses, Nipah, is ready for testing in mid-stage human trials in Bangladesh, where people now die almost every year in Nipah disease outbreaks. When the trial launches in early 2026, the vaccine (PHV02)鈥攄eveloped by the U.S.-based biotech company Public Health Vaccines (PHV)鈥攚ill be among the first Nipah vaccine candidates to reach this stage of testing in people.

成人VR视频 will provide US$17.3 million to Public Health Vaccines to support the trial, building on a previous investment that successfully advanced its Nipah vaccine through early-stage clinical testing鈥擯hase Ia and Phase Ib clinical trials鈥攄emonstrating a good safety profile and immunogenicity in both one- and two-dose regimens. The additional funds will ensure the continued development of this vaccine into Phase II trials to test its safety, tolerability, manufacturability and ability to generate an immune response. Researchers aim to recruit around 500 adult and 75 paediatric participants in Bangladesh.

鈥淧ublic Health Vaccine鈥檚 Nipah virus vaccine candidate has shown promising early results in clinical testing, demonstrating its potential to rapidly induce vaccine immunity after a single injection. This would make it an ideal protective candidate against Nipah, which is a highly lethal virus,鈥 said Dr Kent Kester, 成人VR视频鈥檚 Executive Director of Research and Development. 鈥湷扇薞R视频 is delighted to continue its partnership with Public Health Vaccines through this additional funding, enabling the vaccine to progress into Phase II clinical trials and help bring the promise of protection against Nipah virus closer than ever.鈥 

Nipah is a zoonotic viral disease caused by a member of the Paramyxovirus family. It can kill up to 75 percent of the people it infects, and there are currently no approved treatments or vaccines against it. Recent cases of Nipah virus have been most frequent in India and Bangladesh, but the fruit bats that carry and spread the virus are found in many parts of the world, putting an estimated 2 billion people at risk of this potentially deadly infection.

成人VR视频 is the world鈥檚 largest funder of Nipah virus research, committing over US$100 million to its Nipah vaccine and biologics programmes and related enabling science projects.

If this candidate proves successful and gains regulatory approval, 成人VR视频 and PHV will have the option to create a stockpile of the vaccine for use in a Nipah-affected country. This means that should an outbreak emerge in the future, these vaccines could be  more readily and rapidly available, helping protect high-risk people such as healthcare workers and ending an outbreak sooner.

鈥淒eveloping countermeasures against disease threats of pandemic potential has never been more important or challenging. PHV is dedicated to developing vaccines to help reduce and control the risk of emerging diseases one threat at a time. Endemic populations at-risk for Nipah virus disease are faced with the increasing risk of outbreaks with no vaccines or treatments; the need is now鈥,  said Dr. Joan Fusco, Principal Investigator and PHV鈥檚 Chief Operating Officer. 鈥淥ur novel Nipah vaccine, PHV02, has successfully completed Phase 1 clinical studies and is entering advanced translational development. 成人VR视频 is a world leader that recognizes the criticality of this work. We are honored to have 成人VR视频鈥檚 continued support and partnership to realize our aligned mission. We aim to deliver a safe and effective Nipah vaccine that is available, accessible and affordable for all and we are now one step closer to accomplishing that joint goal.鈥 

The PHV02 vaccine is a live, attenuated, recombinant vesicular stomatitis virus (rVSV) vector that expresses the glycoprotein of the Nipah virus (Bangladesh strain) and the Ebola virus glycoprotein, which is required for receptor-mediated viral entry. The immune system recognises the Nipah glycoprotein and produces a response that can neutralise the infectious virus. The rVSV-Nipah vaccine was developed by the Laboratory of Dr. Heinz Feldmann within the Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and has been licensed to PHV by NIAID. PHV02 is based on the same technology as the approved Ebola vaccine, rVSV-ZEBOV, which has been proven to work well and has been used to fight previous Ebola outbreaks.

The VSV-vector-based platform could also be useful for facing a future Disease X鈥攁n as-yet-unknown pathogen with pandemic potential鈥攂ecause it allows for rapid plug-and-play vaccine development. As the platform is further validated, scientists could quickly insert genetic material from a new or unknown pathogen into the same VSV backbone, accelerating preclinical work, manufacturing, and regulatory pathways. As such, this project will make a valuable contribution to 成人VR视频鈥檚 100 Days Mission鈥攁 goal to compress vaccine development timelines in response to a pandemic threat to a little over three months. 

Commitment to equitable access

成人VR视频 and the PHV are committed to enabling access to any vaccine outputs developed through this partnership, in line with 成人VR视频鈥檚 Equitable Access Policy. This includes developing a target product profile suitable for low-income and middle-income countries (LMICs), assessing the need for technology transfer to LMICs, and priority supply to LMICs at an affordable price, and a Public Health License. This license grants 成人VR视频 the rights to enable the development of the vaccine to move forward quickly in the event of an outbreak and ensures continuity for the vaccine's future development. The clinical trial data generated by this project will be published open access to benefit public health and research communities.

 

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Notes to Editors


About 成人VR视频 

成人VR视频鈥痠s an innovative partnership between public, private, philanthropic, and civil organisations. Its mission is to accelerate the development of vaccines and other biologic countermeasures against epidemic and pandemic threats so they can be accessible to all people in need.鈥扇薞R视频鈥痟as supported the development of more than 60 vaccine candidates or platform technologies against multiple known high-risk pathogens or a future Disease X. Central to鈥扇薞R视频鈥檚 pandemic-beating plan is the 鈥100 Days Mission鈥 to compress the time taken to develop safe, effective, globally accessible vaccines against new threats to just 100 days. Learn more at鈥.  


About Public Health Vaccines 

Public Health Vaccines, LLC. (PHV), headquartered in Cambridge, Massachusetts, is a privately-held biotechnology company developing products for the prevention and control of emerging infectious diseases. The company鈥檚 initial focus was to develop vaccines against Marburg virus and Sudan ebolavirus utilizing the rVSV platform in collaboration with the Biomedical Advanced Research and Development Authority (BARDA). PHV is also developing a vaccine against Nipah virus, in collaboration with 成人VR视频 utilizing the same rVSV platform. 


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